The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo.
نویسندگان
چکیده
Ongoing efforts to unravel the origins of the cholesterol 5,6-secosterols (1a and 1b) in biological systems have revealed that the two known chemical routes to these oxysterols, ozonolysis of cholesterol (3) and Hock-cleavage of 5-alpha-hydroperoxycholesterol (4a), are distinguishable based upon the ratio of the hydrazone derivatives (2a and 2b) formed in each case and this ratio offers an insight into the chemical origin of the secosterols in vivo.
منابع مشابه
A reactive species with a chemical signature similar to that of ozone has been proposed to be generated by the antibody-catalyzed oxidation of water with singlet oxygen during the oxidative burst of activated human neutrophils
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عنوان ژورنال:
- Chemical communications
دوره 21 شماره
صفحات -
تاریخ انتشار 2009